MAPKAP1

MAPKAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VOQ
Identifiers
Aliases	MAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1
External IDs	OMIM: 610558; MGI: 2444554; HomoloGene: 11473; GeneCards: MAPKAP1; OMA:MAPKAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	125,707,234 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	34,624,950 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; apex of heart; ; stromal cell of endometrium; ; oocyte; ; gastrocnemius muscle; ; secondary oocyte; ; right auricle of heart; ; left adrenal cortex; ; left ventricle; ; right adrenal cortex;
	Top expressed in
	zygote; ; genital tubercle; ; secondary oocyte; ; tail of embryo; ; spermatocyte; ; muscle of thigh; ; ventricular zone; ; interventricular septum; ; epithelium of lens; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidic acid binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein kinase binding; phosphatidylinositol-3,4,5-trisphosphate binding;
Cellular component	Golgi apparatus; membrane; plasma membrane; nucleoplasm; cytoplasmic vesicle; nucleus; cytosol; TORC2 complex; cytoplasm;
Biological process	substantia nigra development; negative regulation of Ras protein signal transduction; establishment or maintenance of actin cytoskeleton polarity; stress-activated protein kinase signaling cascade; TORC2 signaling; activation of protein kinase B activity; positive regulation of peptidyl-serine phosphorylation; regulation of cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	79109
	227743
	ENSG00000119487
	ENSMUSG00000038696
	Q9BPZ7
	Q8BKH7
NM_001006617; NM_001006618; NM_001006619; NM_001006620; NM_001006621;
	NM_024117
NM_001290625; NM_001290626; NM_177345; NM_001362919; NM_001362920;
	NM_001362921
NP_001006618; NP_001006619; NP_001006620; NP_001006621; NP_001006622;
	NP_077022
NP_001277554; NP_001277555; NP_796319; NP_001349848; NP_001349849;
	NP_001349850
	Wikidata
View/Edit Human	View/Edit Mouse

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene. As the name indicates, it is a subunit of mTOR complex 2.

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.