MAPKAPK5

MAPKAPK5
Identifiers
Aliases	MAPKAPK5, MAPKAP-K5, MK-5, MK5, PRAK, mitogen-activated protein kinase-activated protein kinase 5, MAPK activated protein kinase 5, NCFD
External IDs	OMIM: 606723; MGI: 1333110; HomoloGene: 69077; GeneCards: MAPKAPK5; OMA:MAPKAPK5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	111,902,222 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,683,968 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of transverse colon; ; jejunal mucosa; ; epithelium of colon; ; gastrocnemius muscle; ; ganglionic eminence; ; ventricular zone; ; body of pancreas; ; skin of leg; ; skin of abdomen;
	Top expressed in
	zone of skin; ; neural layer of retina; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; muscle of thigh; ; esophagus; ; jejunum; ; bone marrow; ; duodenum; ; ovary;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calcium-dependent protein serine/threonine kinase activity; p53 binding; calmodulin binding; kinase activity; protein serine/threonine kinase activity; protein binding; calmodulin-dependent protein kinase activity; ATP binding; MAP kinase kinase activity; mitogen-activated protein kinase binding;
Cellular component	nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	positive regulation of telomere capping; phosphorylation; stress-induced premature senescence; positive regulation of telomere maintenance via telomerase; protein phosphorylation; peptidyl-serine phosphorylation; positive regulation of telomerase activity; protein autophosphorylation; Ras protein signal transduction; regulation of translation; signal transduction; regulation of signal transduction by p53 class mediator; MAPK cascade; cell surface receptor signaling pathway; negative regulation of TOR signaling; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	8550
	17165
	ENSG00000089022
	ENSMUSG00000029454
	Q8IW41
	O54992
NM_003668; NM_139078; NM_001371479; NM_001371480; NM_001371481;
	NM_001371482; NM_001371483; NM_001371484; NM_001371485; NM_001371486; NM_001371487
	NM_010765
NP_003659; NP_620777; NP_001358408; NP_001358409; NP_001358410;
	NP_001358411; NP_001358412; NP_001358413; NP_001358414; NP_001358415; NP_001358416
	NP_034895
	Wikidata
View/Edit Human	View/Edit Mouse

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

A link between Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed. Clinical trials may confirm if this is the case.