MARCO

MARCO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OY3, 2OYA
Identifiers
Aliases	MARCO, SCARA2, macrophage receptor with collagenous structure, SR-A6
External IDs	OMIM: 604870; MGI: 1309998; HomoloGene: 4928; GeneCards: MARCO; OMA:MARCO - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	118,994,660 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	120,432,753 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; visceral pleura; ; synovial membrane; ; synovial joint; ; testicle; ; monocyte; ; parietal pleura; ; lower lobe of lung; ; liver;
	Top expressed in
	stroma of bone marrow; ; mesenteric lymph nodes; ; spleen; ; fetal liver hematopoietic progenitor cell; ; embryo; ; subcutaneous adipose tissue; ; right lung lobe; ; left lobe of liver; ; tunica adventitia of aorta; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scavenger receptor activity; transmembrane signaling receptor activity; pattern recognition receptor activity; amyloid-beta binding; G protein-coupled receptor binding; cargo receptor activity;
Cellular component	integral component of membrane; endocytic vesicle membrane; plasma membrane; collagen; integral component of plasma membrane; membrane; intracellular anatomical structure; cytoplasm;
Biological process	apoptotic cell clearance; cell surface receptor signaling pathway; innate immune response; endocytosis; receptor-mediated endocytosis; immune system process; pattern recognition receptor signaling pathway; positive regulation of protein phosphorylation; phagocytosis, engulfment; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; amyloid-beta clearance;
	Sources:Amigo / QuickGO
Orthologs
	8685
	17167
	ENSG00000019169
	ENSMUSG00000026390
	Q9UEW3
	Q60754
	NM_006770
	NM_010766
	NP_006761
	NP_034896
	Wikidata
View/Edit Human	View/Edit Mouse

Macrophage receptor with collagenous structure (MARCO) is a protein that in humans is encoded by the MARCO gene. MARCO is a class A scavenger receptor that is found on particular subsets of macrophages. Scavenger receptors are pattern recognition receptors (PRRs) found most commonly on immune cells. Their defining feature is that they bind to polyanions and modified forms of a type of cholesterol called low-density lipoprotein (LDL). MARCO is able to bind and phagocytose these ligands and pathogen-associated molecular patterns (PAMPs), leading to the clearance of pathogens and cell signaling events that lead to inflammation. As part of the innate immune system, MARCO clears, or scavenges, pathogens, which leads to inflammatory responses. The scavenger receptor cysteine-rich (SRCR) domain at the end of the extracellular side of MARCO binds ligands to activate the subsequent immune responses. MARCO expression on macrophages has been associated with tumor development and also with Alzheimer's disease, via decreased responses of cells when ligands bind to MARCO.