MARK4

MARK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5ES1
Identifiers
Aliases	MARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D, microtubule affinity regulating kinase 4
External IDs	OMIM: 606495; MGI: 1920955; HomoloGene: 57146; GeneCards: MARK4; OMA:MARK4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,305,284 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,192,746 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; ganglionic eminence; ; prefrontal cortex; ; parotid gland; ; Region I of hippocampus proper; ; stromal cell of endometrium; ; right testis; ; left testis; ; endothelial cell; ; putamen;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; granulocyte; ; lip; ; motor neuron; ; neural layer of retina; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; habenula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; microtubule binding; kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; ubiquitin binding; protein binding; gamma-tubulin binding; ATP binding; tau protein binding;
Cellular component	ciliary basal body; cytosol; centrosome; microtubule cytoskeleton; neuron projection; cytoskeleton; cell projection; cytoplasm; microtubule organizing center; gamma-tubulin complex; dendrite; midbody;
Biological process	phosphorylation; positive regulation of programmed cell death; nervous system development; protein phosphorylation; microtubule bundle formation; cell cycle; cell division; establishment of cell polarity; microtubule cytoskeleton organization; cell projection organization; ciliary basal body-plasma membrane docking; intracellular signal transduction; cilium organization; positive regulation of cilium assembly; regulation of centrosome cycle; positive regulation of protein localization to centrosome;
	Sources:Amigo / QuickGO
Orthologs
	57787
	232944
	ENSG00000007047
	ENSMUSG00000030397
	Q96L34
	Q8CIP4
	NM_001199867; NM_031417
	NM_172279; NM_001368427
	NP_001186796; NP_113605
	NP_758483; NP_001355356
	Wikidata
View/Edit Human	View/Edit Mouse

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene. MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules. Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.

There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau protein in this disease.