MBD1

MBD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IG4, 1D9N, 4D4W
Identifiers
Aliases	MBD1, CXXC3, PCM1, RFT, methyl-CpG binding domain protein 1
External IDs	OMIM: 156535; MGI: 1333811; HomoloGene: 8414; GeneCards: MBD1; OMA:MBD1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,281,774 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	74,415,803 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; parotid gland; ; pituitary gland; ; anterior pituitary; ; skin of leg; ; middle temporal gyrus; ; left ovary; ; right lobe of thyroid gland; ; right ovary;
	Top expressed in
	lacrimal gland; ; lobe of prostate; ; left lobe of liver; ; left colon; ; neural layer of retina; ; vestibular membrane of cochlear duct; ; lumbar subsegment of spinal cord; ; tibiofemoral joint; ; thymus; ; parotid gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; double-stranded methylated DNA binding; zinc ion binding; metal ion binding; protein binding; methyl-CpG binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear speck; nuclear matrix; chromosome; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; DNA methylation-dependent heterochromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	4152
	17190
	ENSG00000141644
	ENSMUSG00000024561
	Q9UIS9
	Q9Z2E2
NM_001204136; NM_001204137; NM_001204138; NM_001204139; NM_001204140;
	NM_001204141; NM_001204142; NM_001204143; NM_001204151; NM_002384; NM_015844; NM_015845; NM_015846; NM_015847; NM_001323942; NM_001323947; NM_001323949; NM_001323950; NM_001323951; NM_001323952; NM_001323953; NM_001323954
	NM_013594; NM_001357421; NM_001357422; NM_001357423
NP_001191065; NP_001191066; NP_001191067; NP_001191068; NP_001191069;
	NP_001191070; NP_001191071; NP_001191072; NP_001191080; NP_001310871; NP_001310876; NP_001310878; NP_001310879; NP_001310880; NP_001310881; NP_001310882; NP_001310883; NP_002375; NP_056669; NP_056670; NP_056671; NP_056723
NP_038622; NP_001344350; NP_001344351; NP_001344352; NP_001389818;
	NP_001389819; NP_001389820; NP_001389821; NP_001389823; NP_001389824
	Wikidata
View/Edit Human	View/Edit Mouse

Methyl-CpG-binding domain protein 1 is a protein that in humans is encoded by the MBD1 gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification.