Membrane-bound transcription factor site-2 protease
| membrane-bound transcription factor peptidase, site 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MBTPS2 | ||||||
| Alt. symbols | S2P | ||||||
| NCBI gene | 51360 | ||||||
| HGNC | 15455 | ||||||
| OMIM | 300294 | ||||||
| RefSeq | NM_015884 | ||||||
| UniProt | O43462 | ||||||
| Other data | |||||||
| EC number | 3.4.24.85 | ||||||
| Locus | Chr. X p22.1-p22.2 | ||||||
| |||||||
| S2P endopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.24.85 | ||||||||
| CAS no. | 752251-31-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Membrane-bound transcription factor site-2 protease, also known as S2P endopeptidase or site-2 protease (S2P), is an enzyme (EC 3.4.24.85) encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) transcription factors from membranes. S2P cleaves the transmembrane domain of SREBP, making it a member of the class of intramembrane proteases.
S2P catalyses the following chemical reaction
- Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional activator ATF6.
This enzyme belongs to the peptidase family M50.