Melanocortin 4 receptor

MC4R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IQP, 2IQR, 2IQS, 2IQU, 2IQV, 2IQW
Identifiers
Aliases	MC4R, Melanocortin 4 receptor, BMIQ20
External IDs	OMIM: 155541; MGI: 99457; HomoloGene: 4320; GeneCards: MC4R; OMA:MC4R - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	60,372,775 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	66,993,577 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; prefrontal cortex; ; Hypothalamus; ; caudate nucleus; ; anterior cingulate cortex; ; Brodmann area 9; ; putamen; ; nucleus accumbens; ; right frontal lobe; ; Amygdala;
	Top expressed in
	embryo; ; embryo; ; embryo; ; thyroid gland; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; neural tube; ; primary visual cortex; ; striatum of neuraxis; ; Cortex of frontal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; peptide hormone binding; melanocyte-stimulating hormone receptor activity; protein binding; melanocortin receptor activity; ubiquitin protein ligase binding; neuropeptide binding; hormone binding;
Cellular component	integral component of membrane; membrane; plasma membrane; nucleus;
Biological process	regulation of grooming behavior; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; insulin secretion; regulation of feeding behavior; positive regulation of bone resorption; diet induced thermogenesis; response to insulin; feeding behavior; negative regulation of feeding behavior; energy reserve metabolic process; regulation of metabolic process; signal transduction; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4160
	17202
	ENSG00000166603
	ENSMUSG00000047259
	P32245
	P56450
	NM_005912
	NM_016977
	NP_005903
	NP_058673
	Wikidata
View/Edit Human	View/Edit Mouse

The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in regulating energy homeostasis, appetite, and sexual function. It plays a key role in metabolic processes and is predisposes to certain forms of obesity in humans. MC4R is a receptor that is activated by α-melanocyte-stimulating hormone (α-MSH), influencing energy homeostasis and feeding behavior in the central nervous system. In [[mouse models]], MC4R has been shown to regulate feeding behavior, metabolism, reproductive function, and erectile response.