MCC (gene)

MCC
Identifiers
Aliases	MCC, MCC1, mutated in colorectal cancers, WNT signaling pathway regulator, MCC regulator of WNT signaling pathway
External IDs	OMIM: 159350; MGI: 96930; HomoloGene: 20539; GeneCards: MCC; OMA:MCC - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	113,488,823 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	44,945,249 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; sural nerve; ; skin of hip; ; left ovary; ; germinal epithelium; ; skin of thigh; ; retinal pigment epithelium; ; endothelial cell; ; seminal vesicula; ; pars reticulata;
	Top expressed in
	zygote; ; otolith organ; ; utricle; ; lobe of cerebellum; ; cerebellar vermis; ; secondary oocyte; ; gastrula; ; ventral tegmental area; ; iris; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor activity;
Cellular component	cytoplasm; plasma membrane; cell projection; membrane; nucleus; lamellipodium; nucleoplasm; cytosol;
Biological process	establishment of protein localization; negative regulation of epithelial cell proliferation; negative regulation of epithelial cell migration; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4163
	328949
	ENSG00000171444
	ENSMUSG00000071856
	P23508
	n/a
	NM_001085377; NM_002387
	NM_001033406; NM_001085373; NM_001085374
	NP_001078846; NP_002378
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.