MCM8

MCM8
Identifiers
Aliases	MCM8, C20orf154, dJ967N21.5, POF10, minichromosome maintenance 8 homologous recombination repair factor
External IDs	OMIM: 608187; MGI: 1913884; HomoloGene: 12001; GeneCards: MCM8; OMA:MCM8 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	5,998,977 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	132,686,117 bp
RNA expression pattern
	Top expressed in
	gonad; ; buccal mucosa cell; ; oocyte; ; testicle; ; secondary oocyte; ; trabecular bone; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; ventricular zone; ; bone marrow cells;
	Top expressed in
	tail of embryo; ; genital tubercle; ; epiblast; ; hand; ; secondary oocyte; ; embryo; ; zygote; ; ventricular zone; ; embryo; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; hydrolase activity; DNA binding; nucleotide binding; helicase activity; protein binding; chromatin binding; enzyme binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; DNA replication origin binding; single-stranded DNA binding;
Cellular component	MCM8-MCM9 complex; nucleus; nucleoplasm; chromosome; MCM complex;
Biological process	female gamete generation; DNA repair; male gamete generation; DNA replication; cell cycle; double-strand break repair via homologous recombination; cellular response to DNA damage stimulus; DNA replication initiation; G1/S transition of mitotic cell cycle; recombinational interstrand cross-link repair; protein stabilization; protein localization to chromatin;
	Sources:Amigo / QuickGO
Orthologs
	84515
	66634
	ENSG00000125885
	ENSMUSG00000027353
	Q9UJA3
	Q9CWV1
	NM_001281520; NM_001281521; NM_001281522; NM_032485; NM_182802
	NM_001291054; NM_025676
	NP_001268449; NP_001268450; NP_001268451; NP_115874; NP_877954
	NP_001277983; NP_079952
	Wikidata
View/Edit Human	View/Edit Mouse

DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.