MDC1

MDC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ADO, 2AZM, 2ETX, 3K05, 3UEO, 3UMZ, 3UN0, 3UNM, 3UNN, 3UOT
Identifiers
Aliases	MDC1, NFBD1, mediator of DNA damage checkpoint 1
External IDs	OMIM: 607593; MGI: 3525201; HomoloGene: 67092; GeneCards: MDC1; OMA:MDC1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,717,447 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,170,562 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right lobe of thyroid gland; ; ventricular zone; ; left lobe of thyroid gland; ; right ovary; ; left ovary; ; gastric mucosa; ; body of uterus; ; pituitary gland;
	Top expressed in
	tail of embryo; ; spermatocyte; ; genital tubercle; ; zygote; ; cumulus cell; ; spermatid; ; hand; ; yolk sac; ; ventricular zone; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	FHA domain binding; protein C-terminus binding; protein binding; identical protein binding;
Cellular component	nucleus; focal adhesion; chromosome; nucleoplasm; nuclear body;
Biological process	cellular response to DNA damage stimulus; mitotic intra-S DNA damage checkpoint signaling; cell cycle; double-strand break repair via nonhomologous end joining; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	9656
	240087
ENSG00000224587; ENSG00000237095; ENSG00000137337; ENSG00000206481; ENSG00000234012;
	ENSG00000231135; ENSG00000228575; ENSG00000225589
	ENSMUSG00000061607
	Q14676
	Q5PSV9
	NM_014641
	NM_001010833
	NP_055456
NP_001010833; NP_001392450; NP_001392451; NP_001392452; NP_001392453;
	NP_001392454; NP_001392455; NP_001392456; NP_001392457; NP_001392458
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell survival fate in association with tumor suppressor protein p53. This protein also goes by the name Nuclear Factor with BRCT Domain 1 (NFBD1).