ME1 (gene)

ME1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AW5, 3WJA
Identifiers
Aliases	ME1, HUMNDME, MES, malic enzyme 1
External IDs	OMIM: 154250; MGI: 97043; HomoloGene: 134785; GeneCards: ME1; OMA:ME1 - orthologs
EC number	1.1.1.40
Gene location (Human)
Chr.	Chromosome 6 (human)
End	83,431,051 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	86,578,006 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; spinal ganglia; ; trigeminal ganglion; ; pars compacta; ; skin of thigh; ; pars reticulata; ; right adrenal cortex; ; vulva; ; gums; ; gingival epithelium;
	Top expressed in
	adrenal gland; ; lactiferous gland; ; tunica adventitia of aorta; ; mucous cell of stomach; ; pyloric antrum; ; right kidney; ; epithelium of stomach; ; subcutaneous adipose tissue; ; brown adipose tissue; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	manganese ion binding; ADP binding; NAD binding; metal ion binding; NADP binding; electron transfer activity; malate dehydrogenase (decarboxylating) (NAD+) activity; oxidoreductase activity; oxaloacetate decarboxylase activity; malic enzyme activity; malate dehydrogenase (decarboxylating) (NADP+) activity;
Cellular component	cytoplasm; cytosol; mitochondrion;
Biological process	regulation of NADP metabolic process; protein tetramerization; NADP biosynthetic process; response to hormone; response to carbohydrate; malate metabolic process; regulation of lipid metabolic process; carbohydrate metabolic process; electron transport chain; pyruvate metabolic process; nucleotide biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4199
	17436
	ENSG00000065833
	ENSMUSG00000032418
	P48163
	P06801
	NM_002395
	NM_001198933; NM_008615
	NP_002386
	NP_001185862; NP_032641
	Wikidata
View/Edit Human	View/Edit Mouse

NADP-dependent malic enzyme is a protein that in humans is encoded by the ME1 gene.

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate to pyruvate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.