ME2 (gene)

ME2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DO8, 1EFK, 1EFL, 1GZ3, 1GZ4, 1PJ2, 1PJ3, 1PJ4, 1PJL, 1QR6
Identifiers
Aliases	ME2, ODS1, malic enzyme 2
External IDs	OMIM: 154270; MGI: 2147351; HomoloGene: 37615; GeneCards: ME2; OMA:ME2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,954,257 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; jejunal mucosa; ; cardiac muscle tissue of right atrium; ; mucosa of colon; ; mucosa of sigmoid colon; ; monocyte; ; duodenum; ; right ventricle; ; myocardium of left ventricle; ; rectum;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	malate dehydrogenase (decarboxylating) (NAD+) activity; electron transfer activity; oxidoreductase activity; NAD binding; oxaloacetate decarboxylase activity; catalytic activity; metal ion binding; malic enzyme activity; malate dehydrogenase (decarboxylating) (NADP+) activity;
Cellular component	mitochondrion; mitochondrial matrix;
Biological process	regulation of NADP metabolic process; metabolism; pyruvate metabolic process; malate metabolic process; electron transport chain; tricarboxylic acid cycle;
	Sources:Amigo / QuickGO
Orthologs
	4200
	107029
	ENSG00000082212
	n/a
	P23368
	Q99KE1
	NM_001168335; NM_002396
	NM_145494
	NP_001161807; NP_002387
	NP_663469
	Wikidata
View/Edit Human	View/Edit Mouse

NAD-dependent malic enzyme, mitochondrial is a protein that in humans is encoded by the ME2 gene. This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.