MECOM

MECOM
Identifiers
Aliases	MECOM, AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2, MDS1 and EVI1 complex locus, KMT8E
External IDs	OMIM: 165215; MGI: 95457; HomoloGene: 21086; GeneCards: MECOM; OMA:MECOM - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	169,663,775 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	30,602,157 bp
RNA expression pattern
	Top expressed in
	cardia; ; renal medulla; ; pylorus; ; nasal epithelium; ; mucosa of paranasal sinus; ; bronchial epithelial cell; ; visceral pleura; ; mucosa of urinary bladder; ; mucosa of sigmoid colon; ; lower lobe of lung;
	Top expressed in
	transitional epithelium of urinary bladder; ; epithelium of stomach; ; Paneth cell; ; left lung lobe; ; renal corpuscle; ; medullary collecting duct; ; endocardial cushion; ; left colon; ; lacrimal gland; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; metal ion binding; protein binding; nucleic acid binding; histone-lysine N-methyltransferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; histone methyltransferase activity (H3-K9 specific); methyltransferase activity; transferase activity;
Cellular component	histone deacetylase complex; cytosol; nuclear speck; nucleus; nucleoplasm; cytoplasm;
Biological process	cell differentiation; regulation of transcription, DNA-templated; hematopoietic stem cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-templated; regulation of cell cycle; positive regulation of transcription, DNA-templated; multicellular organism development; negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-templated; apoptotic process; histone lysine methylation; regulation of transcription by RNA polymerase II; histone H3-K9 methylation; heterochromatin organization; methylation;
	Sources:Amigo / QuickGO
Orthologs
	2122
	14013
	ENSG00000085276
	ENSMUSG00000027684
	Q03112
	P14404
NM_001105077; NM_001105078; NM_001163999; NM_001164000; NM_001205194;
	NM_004991; NM_005241; NM_001366466; NM_001366467; NM_001366468; NM_001366469; NM_001366470; NM_001366471; NM_001366472; NM_001366473; NM_001366474
	NM_007963; NM_021442; NM_001361034; NM_001370768; NM_001370769
NP_001098547; NP_001098548; NP_001157471; NP_001157472; NP_001192123;
	NP_004982; NP_005232; NP_001353395; NP_001353396; NP_001353397; NP_001353398; NP_001353399; NP_001353400; NP_001353401; NP_001353402; NP_001353403; NP_004982.2
NP_031989; NP_067417; NP_001347963; NP_001357697; NP_001357698;
	NP_067417.1
	Wikidata
View/Edit Human	View/Edit Mouse

MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.