MED14

MED14
Identifiers
Aliases	MED14, CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170, mediator complex subunit 14
External IDs	OMIM: 300182; MGI: 1349442; HomoloGene: 22082; GeneCards: MED14; OMA:MED14 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	40,735,858 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	12,628,312 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; cartilage tissue; ; muscle of thigh; ; gastrocnemius muscle; ; ventricular zone; ; vastus lateralis muscle; ; biceps brachii; ; skeletal muscle tissue; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	genital tubercle; ; tail of embryo; ; medullary collecting duct; ; hair follicle; ; condyle; ; renal corpuscle; ; secondary oocyte; ; endocardial cushion; ; atrioventricular valve; ; conjunctival fornix;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; transcription coregulator activity; protein binding; nuclear receptor coactivator activity; vitamin D receptor binding; signaling receptor activity;
Cellular component	membrane; core mediator complex; mediator complex; nucleoplasm; nucleus;
Biological process	androgen receptor signaling pathway; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; intracellular steroid hormone receptor signaling pathway; transcription, DNA-templated; stem cell population maintenance; positive regulation of transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9282
	26896
	ENSG00000180182
	ENSMUSG00000064127
	O60244
	A2ABV5
	NM_004229
	NM_001048208; NM_012005
	NP_004220
	NP_001041673; NP_036135
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.