MED17

MED17
Identifiers
Aliases	MED17, CRSP6, CRSP77, DRIP80, TRAP80, mediator complex subunit 17, SRB4
External IDs	OMIM: 603810; MGI: 2182585; HomoloGene: 3151; GeneCards: MED17; OMA:MED17 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	93,814,963 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	15,191,227 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; left ovary; ; right ovary; ; canal of the cervix; ; stromal cell of endometrium; ; granulocyte; ; body of uterus;
	Top expressed in
	primary oocyte; ; granulocyte; ; zygote; ; secondary oocyte; ; epiblast; ; ventricular zone; ; morula; ; endocardial cushion; ; abdominal wall; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coregulator activity; thyroid hormone receptor binding; protein binding; nuclear receptor coactivator activity; vitamin D receptor binding; transcription coactivator activity; signaling receptor activity; ubiquitin protein ligase activity;
Cellular component	membrane; transcription regulator complex; nucleoplasm; mediator complex; nucleus; core mediator complex; ubiquitin ligase complex;
Biological process	androgen receptor signaling pathway; regulation of transcription, DNA-templated; intracellular steroid hormone receptor signaling pathway; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; protein ubiquitination; stem cell population maintenance;
	Sources:Amigo / QuickGO
Orthologs
	9440
	234959
	ENSG00000042429
	ENSMUSG00000031935
	Q9NVC6
	Q8VCD5
	NM_004268
	NM_144933; NM_001364533
	NP_004259
	NP_659182; NP_001351462
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.