MED26

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Med26
Med26
	solution structure of the n-terminal domain i of mouse transcription elongation factor s-ii protein 3
Identifiers
Symbol	Med26 N-terminal domain
Pfam	PF08711
InterPro	IPR017923
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

MED26
Identifiers
Aliases	MED26, CRSP7, CRSP70, mediator complex subunit 26
External IDs	OMIM: 605043; MGI: 1917875; HomoloGene: 68417; GeneCards: MED26; OMA:MED26 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,629,062 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	73,302,114 bp
RNA expression pattern
	Top expressed in
	sperm; ; amniotic fluid; ; buccal mucosa cell; ; tibialis anterior muscle; ; nipple; ; skin of arm; ; mucosa of ileum; ; left testis; ; right testis; ; secondary oocyte;
	Top expressed in
	seminiferous tubule; ; secondary oocyte; ; primary oocyte; ; spermatocyte; ; zygote; ; spermatid; ; granulocyte; ; muscle of thigh; ; medullary collecting duct; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; transcription coregulator activity; protein binding;
Cellular component	mediator complex; nucleus; nucleoplasm; core mediator complex;
Biological process	regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription; positive regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	9441
	70625
	ENSG00000105085
	ENSMUSG00000045248
	O95402
	Q7TN02
	NM_004831
	NM_027485
	NP_004822
	NP_081761
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator subunit 26 Middle domain

Identifiers

Symbol

Med26_M

Pfam

PF15694

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Mediator subunit 26 C-terminal domain

Identifiers

Symbol

Med26_C

Pfam

PF15693

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene. It forms part of the Mediator complex.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.