MED27

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Med27
Med27
Identifiers
Symbol	Med27
Pfam	PF11571
InterPro	IPR021627
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

MED27
Identifiers
Aliases	MED27, CRAP34, CRSP34, CRSP8, TRAP37, MED3, mediator complex subunit 27, NEDSCAC
External IDs	OMIM: 605044; MGI: 1916225; HomoloGene: 3152; GeneCards: MED27; OMA:MED27 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	132,079,867 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	29,414,805 bp
RNA expression pattern
	Top expressed in
	oocyte; ; endothelial cell; ; secondary oocyte; ; ganglionic eminence; ; islet of Langerhans; ; popliteal artery; ; tibial arteries; ; thoracic aorta; ; ascending aorta; ; ventricular zone;
	Top expressed in
	zygote; ; superior surface of tongue; ; gallbladder; ; plantaris muscle; ; extensor digitorum longus muscle; ; entorhinal cortex; ; perirhinal cortex; ; corneal stroma; ; secondary oocyte; ; CA3 field;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; protein binding; ubiquitin protein ligase activity;
Cellular component	mediator complex; nucleolus; nucleus; transcription regulator complex; nucleoplasm; ubiquitin ligase complex; cytosol;
Biological process	regulation of transcription by RNA polymerase II; stem cell population maintenance; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; protein ubiquitination; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	9442
	68975
	ENSG00000160563
	ENSMUSG00000026799
	Q6P2C8
	Q9DB40
	NM_001253881; NM_001253882; NM_004269
	NM_001290489; NM_026896; NM_029615; NM_001290490
	NP_001240810; NP_001240811; NP_004260
	NP_001277418; NP_001277419; NP_081172; NP_083891
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 27 is an enzyme that in humans is encoded by the MED27 gene. It forms part of the Mediator complex.

The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.