MED7

MED7
Identifiers
Aliases	MED7, ARC34, CRSP33, CRSP9, mediator complex subunit 7
External IDs	OMIM: 605045; MGI: 1913463; HomoloGene: 3153; GeneCards: MED7; OMA:MED7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	157,159,019 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	46,333,548 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; sperm; ; germinal epithelium; ; endothelial cell; ; Achilles tendon; ; palpebral conjunctiva; ; kidney tubule; ; corpus epididymis; ; testicle; ; gonad;
	Top expressed in
	medullary collecting duct; ; secondary oocyte; ; renal corpuscle; ; lens; ; primary oocyte; ; atrioventricular valve; ; seminiferous tubule; ; tail of embryo; ; medial ganglionic eminence; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; transcription coregulator activity; protein binding; ubiquitin protein ligase activity;
Cellular component	mediator complex; nucleus; transcription regulator complex; nucleoplasm; ubiquitin ligase complex; nuclear body;
Biological process	regulation of transcription by RNA polymerase II; stem cell population maintenance; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; protein ubiquitination; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	9443
	66213
	ENSG00000155868
	ENSMUSG00000020397
	O43513
	Q9CZB6
	NM_004270; NM_001100816
	NM_001104530; NM_001104556; NM_001104557; NM_025426
	NP_001094286; NP_004261
	NP_001098000; NP_001098026; NP_001098027; NP_079702
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.