Myocyte-specific enhancer factor 2A

MEF2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C7U, 1EGW, 1LEW, 3KOV, 3MU6, 3P57
Identifiers
Aliases	MEF2A, ADCAD1, RSRFC4, RSRFC9, mef2, myocyte enhancer factor 2A
External IDs	OMIM: 600660; MGI: 99532; HomoloGene: 4080; GeneCards: MEF2A; OMA:MEF2A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	99,716,488 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	67,372,858 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; myocardium; ; cardiac muscle tissue of right atrium; ; right ventricle; ; myocardium of left ventricle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; skin of thigh; ; middle temporal gyrus; ; tibia;
	Top expressed in
	medial dorsal nucleus; ; lateral geniculate nucleus; ; lateral septal nucleus; ; medial geniculate nucleus; ; atrioventricular valve; ; stroma of bone marrow; ; right ventricle; ; atrium; ; cerebellar vermis; ; ankle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; transcription coactivator activity; DNA binding; protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; histone acetyltransferase binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; SMAD binding; protein kinase binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleoplasm; nucleus; cytosol;
Biological process	cellular response to calcium ion; cell differentiation; regulation of transcription, DNA-templated; mitochondrial genome maintenance; dendrite morphogenesis; positive regulation of muscle cell differentiation; muscle organ development; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; ERK5 cascade; multicellular organism development; positive regulation of transcription, DNA-templated; heart development; cardiac conduction; mitochondrion distribution; ventricular cardiac myofibril assembly; positive regulation of transcription by RNA polymerase II; apoptotic process; positive regulation of cardiac muscle hypertrophy; transcription by RNA polymerase II; MAPK cascade; positive regulation of glucose import;
	Sources:Amigo / QuickGO
Orthologs
	4205
	17258
	ENSG00000068305
	ENSMUSG00000030557
	Q02078
	Q60929
NM_001130926; NM_001130927; NM_001130928; NM_001171894; NM_005587;
	NM_001319206; NM_001352614; NM_001352615; NM_001352616; NM_001352617; NM_001352618; NM_001365201; NM_001365202; NM_001365203; NM_001365204; NM_001365205; NM_001365206; NM_001365207; NM_001365208; NM_001365209; NM_001365210; NM_001365211; NM_001393558; NM_001393559; NM_001393560; NM_001393561
NM_001033713; NM_001291191; NM_001291192; NM_001291195; NM_001291196;
	NM_001357324; NM_001357325
NP_001124398; NP_001124399; NP_001124400; NP_001165365; NP_001306135;
	NP_005578; NP_001339543; NP_001339544; NP_001339545; NP_001339546; NP_001339547; NP_001352130; NP_001352131; NP_001352132; NP_001352133; NP_001352134; NP_001352135; NP_001352136; NP_001352137; NP_001352138; NP_001352139; NP_001352140
NP_001028885; NP_001278120; NP_001278121; NP_001278124; NP_001278125;
	NP_001344253; NP_001344254
	Wikidata
View/Edit Human	View/Edit Mouse

Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.