MEF2C

MEF2C
Identifiers
Aliases	MEF2C, C5DELq14.3, DEL5q14.3, myocyte enhancer factor 2C
External IDs	OMIM: 600662; MGI: 99458; HomoloGene: 31087; GeneCards: MEF2C; OMA:MEF2C - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	88,904,257 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; glutes; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Brodmann area 23; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; triceps brachii muscle; ; orbitofrontal cortex; ; frontal pole;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II general transcription initiation factor activity; core promoter sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; HMG box domain binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; minor groove of adenine-thymine-rich DNA binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nuclear speck; intracellular membrane-bounded organelle; nucleoplasm; cytoplasm; postsynapse; sarcoplasm; protein-containing complex;
Biological process	negative regulation of neuron apoptotic process; embryonic skeletal system morphogenesis; myotube differentiation; positive regulation of skeletal muscle tissue development; cell morphogenesis involved in neuron differentiation; positive regulation of muscle cell differentiation; regulation of synapse assembly; muscle organ development; outflow tract morphogenesis; monocyte differentiation; sinoatrial valve morphogenesis; negative regulation of ossification; heart looping; positive regulation of skeletal muscle cell differentiation; blood vessel remodeling; blood vessel development; positive regulation of cardiac muscle cell proliferation; humoral immune response; positive regulation of alkaline phosphatase activity; negative regulation of epithelial cell proliferation; regulation of synaptic transmission, glutamatergic; melanocyte differentiation; apoptotic process; B cell receptor signaling pathway; cellular response to calcium ion; cellular response to transforming growth factor beta stimulus; renal tubule morphogenesis; nephron tubule epithelial cell differentiation; cell fate commitment; cardiac ventricle formation; regulation of transcription, DNA-templated; cardiac muscle cell differentiation; regulation of neuron apoptotic process; platelet formation; neuron development; smooth muscle cell differentiation; positive regulation of protein homodimerization activity; negative regulation of gene expression; transcription, DNA-templated; cellular response to trichostatin A; positive regulation of transcription, DNA-templated; heart development; epithelial cell proliferation involved in renal tubule morphogenesis; cardiac muscle hypertrophy in response to stress; positive regulation of B cell proliferation; positive regulation of neuron differentiation; excitatory postsynaptic potential; learning or memory; positive regulation of macrophage apoptotic process; positive regulation of cardiac muscle cell differentiation; cellular response to parathyroid hormone stimulus; primary heart field specification; secondary heart field specification; regulation of dendritic spine development; regulation of germinal center formation; roof of mouth development; cell differentiation; chondrocyte differentiation; positive regulation of bone mineralization; neural crest cell differentiation; neuron migration; B cell homeostasis; negative regulation of transcription by RNA polymerase II; endochondral ossification; regulation of neurotransmitter secretion; cellular response to fluid shear stress; nervous system development; regulation of synaptic plasticity; regulation of NMDA receptor activity; muscle cell fate determination; positive regulation of osteoblast differentiation; regulation of synaptic activity; osteoblast differentiation; neuron differentiation; regulation of sarcomere organization; skeletal muscle cell differentiation; positive regulation of behavioral fear response; glomerulus morphogenesis; germinal center formation; positive regulation of cell proliferation in bone marrow; MAPK cascade; regulation of AMPA receptor activity; multicellular organism development; B cell proliferation; positive regulation of gene expression; positive regulation of myoblast differentiation; cartilage morphogenesis; embryonic viscerocranium morphogenesis; ventricular cardiac muscle cell differentiation; cellular response to lipopolysaccharide; skeletal muscle tissue development; regulation of megakaryocyte differentiation; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of blood vessel endothelial cell migration; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4208
	17260
	ENSG00000081189
	ENSMUSG00000005583
	Q06413
	Q8CFN5
NM_001131005; NM_001193347; NM_001193348; NM_001193349; NM_001193350;
	NM_001308002; NM_002397; NM_001363581
	NM_001170537; NM_025282
NP_001124477; NP_001180276; NP_001180277; NP_001180278; NP_001180279;
	NP_001294931; NP_002388; NP_001350510; NP_001351258; NP_001351259; NP_001351260; NP_001351261; NP_001351262; NP_001351263; NP_001351264; NP_001351265; NP_001351266; NP_001351267; NP_001351268; NP_001351269; NP_001351270; NP_001351271; NP_001351272; NP_001351273; NP_001351274; NP_001351275; NP_001351276; NP_001351277; NP_001351278; NP_001351279; NP_001351281; NP_001351282; NP_001351283; NP_001351284; NP_001351285; NP_001351286; NP_001294931.1
NP_001164008; NP_001334493; NP_001334495; NP_001334496; NP_001334497;
	NP_001334498; NP_001334500; NP_001334501; NP_001334502; NP_001334503; NP_001334504; NP_001334505; NP_001334506; NP_001334507; NP_001334508; NP_001334509; NP_001334510; NP_079558
	Wikidata
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Myocyte-specific enhancer factor 2C also known as MADS box transcription enhancer factor 2, polypeptide C is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family.