MEN1

MEN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9, 5DDA, 5DDE, 5DDB, 5DDD, 5DDC, 5DB0, 5DB3, 5DB1, 5DB2
Identifiers
Aliases	MEN1, MEAI, SCG2, menin 1
External IDs	OMIM: 613733; MGI: 1316736; HomoloGene: 7418; GeneCards: MEN1; OMA:MEN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,811,294 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,390,921 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right hemisphere of cerebellum; ; right adrenal gland; ; ganglionic eminence; ; ventricular zone; ; mucosa of transverse colon; ; right adrenal cortex; ; right lobe of liver; ; right lobe of thyroid gland; ; left adrenal gland;
	Top expressed in
	genital tubercle; ; tail of embryo; ; epiblast; ; ventricular zone; ; ganglionic eminence; ; yolk sac; ; adrenal gland; ; striatum of neuraxis; ; Mesencephalon; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein-macromolecule adaptor activity; R-SMAD binding; protein N-terminus binding; chromatin binding; histone-lysine N-methyltransferase activity; protein binding; four-way junction DNA binding; Y-form DNA binding; double-stranded DNA binding;
Cellular component	cytoplasm; cytosol; nuclear matrix; nucleoplasm; chromatin; cleavage furrow; nucleus; histone methyltransferase complex; endoplasmic reticulum lumen; protein-containing complex;
Biological process	negative regulation of cell-substrate adhesion; negative regulation of protein phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-templated; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of telomerase activity; negative regulation of cell cycle; regulation of activin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; negative regulation of osteoblast differentiation; negative regulation of cell cycle G1/S phase transition; MAPK cascade; cellular response to DNA damage stimulus; negative regulation of JNK cascade; brain development; cellular response to peptide hormone stimulus; decidualization; negative regulation of epithelial cell proliferation; mitotic cell cycle; osteoblast development; positive regulation of protein binding; negative regulation of transcription, DNA-templated; response to gamma radiation; response to UV; type B pancreatic cell differentiation; DNA repair; regulation of type B pancreatic cell proliferation; cellular response to glucose stimulus; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; response to transforming growth factor beta; histone lysine methylation; beta-catenin-TCF complex assembly; transcription, DNA-templated; post-translational protein modification; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	4221
	17283
	ENSG00000133895
	ENSMUSG00000024947
	O00255
	O88559
NM_000244; NM_130799; NM_130800; NM_130801; NM_130802;
	NM_130803; NM_130804; NM_001370251; NM_001370259; NM_001370260; NM_001370261; NM_001370262; NM_001370263
	NM_001168488; NM_001168489; NM_001168490; NM_008583
NP_000235; NP_570711; NP_570712; NP_570713; NP_570714;
	NP_570715; NP_570716; NP_001357180; NP_001357188; NP_001357189; NP_001357190; NP_001357191; NP_001357192
	NP_001161960; NP_001161961; NP_001161962; NP_032609
	Wikidata
View/Edit Human	View/Edit Mouse

Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. Variations in the MEN1 gene can cause pituitary adenomas, hyperparathyroidism, pancreatic neuroendocrine tumors, gastrinoma, and adrenocortical cancers.

In vitro studies have shown that menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. However, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the coding sequence. Five variants where alternative splicing takes place in the 5' UTR have also been identified.