MERTK

MERTK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DBJ, 2P0C, 3BPR, 3BRB, 3TCP, 4M3Q, 4MH7, 4MHA
Identifiers
Aliases	MERTK, MER, RP38, c-mer, Tyro12, c-Eyk, MER proto-oncogene, tyrosine kinase
External IDs	OMIM: 604705; MGI: 96965; HomoloGene: 4626; GeneCards: MERTK; OMA:MERTK - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	112,029,561 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	128,644,814 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; gastric mucosa; ; left adrenal gland; ; left adrenal cortex; ; popliteal artery; ; tibial arteries; ; Descending thoracic aorta; ; ascending aorta; ; left coronary artery; ; spleen;
	Top expressed in
	stroma of bone marrow; ; tunica media of zone of aorta; ; retinal pigment epithelium; ; jejunum; ; ascending aorta; ; ileum; ; body of femur; ; spleen; ; duodenum; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; protein tyrosine kinase activity; protein kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; nucleotide binding; transferase activity; receptor tyrosine kinase; transmembrane signaling receptor activity; Wnt-protein binding;
Cellular component	integral component of membrane; photoreceptor outer segment; rhabdomere; membrane; integral component of plasma membrane; plasma membrane; cytoplasm; extracellular space; receptor complex;
Biological process	spermatogenesis; vagina development; protein kinase B signaling; natural killer cell differentiation; cell surface receptor signaling pathway; protein phosphorylation; platelet activation; cell-cell signaling; positive regulation of phagocytosis; apoptotic cell clearance; substrate adhesion-dependent cell spreading; leukocyte migration; negative regulation of lymphocyte activation; phosphorylation; retina development in camera-type eye; negative regulation of leukocyte apoptotic process; phagocytosis; secretion by cell; peptidyl-tyrosine phosphorylation; negative regulation of cytokine production; neutrophil clearance; negative regulation of signal transduction; Wnt signaling pathway; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development; cell migration;
	Sources:Amigo / QuickGO
Orthologs
	10461
	17289
	ENSG00000153208
	ENSMUSG00000014361
	Q12866
	Q60805
	NM_006343
	NM_008587
	NP_006334
	NP_032613
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene.