MESP1

MESP1
Identifiers
Aliases	MESP1, bHLHc5, mesoderm posterior bHLH transcription factor 1
External IDs	OMIM: 608689; MGI: 107785; HomoloGene: 32039; GeneCards: MESP1; OMA:MESP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	89,751,249 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,443,536 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; oocyte; ; testicle; ; nasal epithelium; ; secondary oocyte; ; prefrontal cortex; ; Amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; muscle of thigh;
	Top expressed in
	seminiferous tubule; ; spermatocyte; ; spermatid; ; embryo; ; morula; ; epiblast; ; primitive streak; ; right ventricle; ; embryo; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	Notch signaling pathway; neurogenesis; cardiac ventricle formation; regulation of transcription, DNA-templated; lateral mesoderm development; positive regulation of hepatocyte differentiation; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; negative regulation of mesodermal cell fate specification; cardiac muscle cell differentiation; positive regulation of Notch signaling pathway involved in heart induction; cardiac vascular smooth muscle cell differentiation; signal transduction involved in regulation of gene expression; heart morphogenesis; transcription by RNA polymerase II; transcription, DNA-templated; sinus venosus morphogenesis; heart looping; positive regulation of transcription, DNA-templated; cardioblast migration; cardiac cell fate determination; multicellular organism development; gastrulation; embryonic heart tube morphogenesis; growth involved in heart morphogenesis; positive regulation of striated muscle cell differentiation; cardioblast migration to the midline involved in heart field formation; endothelial cell differentiation; sinoatrial node cell differentiation; negative regulation of endodermal cell fate specification; secondary heart field specification; cardiac atrium formation; negative regulation of transcription, DNA-templated; cardioblast anterior-lateral migration; mesodermal cell migration; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; mesoderm formation; somitogenesis; embryonic pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	55897
	17292
	ENSG00000166823
	ENSMUSG00000030544
	Q9BRJ9
	P97309
	NM_018670
	NM_008588
	NP_061140
	NP_032614
	Wikidata
View/Edit Human	View/Edit Mouse

Mesoderm posterior 1 homolog (mouse) is a protein that in humans is encoded by the MESP1 gene. MESP1 is a transcription factor that regulates cardiovascular progenitor specification.