Mesoderm-specific transcript homolog protein

MEST
Identifiers
Aliases	MEST, PEG1, mesoderm specific transcript
External IDs	OMIM: 601029; MGI: 96968; HomoloGene: 1800; GeneCards: MEST; OMA:MEST - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	130,506,465 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,748,465 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; placenta; ; secondary oocyte; ; pericardium; ; parietal pleura; ; ventricular zone; ; abdominal fat; ; embryo; ; lactiferous duct; ; right adrenal gland;
	Top expressed in
	mandibular prominence; ; dermis; ; left lung lobe; ; human fetus; ; atrium; ; abdominal wall; ; genital tubercle; ; maxillary prominence; ; efferent ductule; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	catalytic activity; hydrolase activity;
Cellular component	integral component of membrane; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	mesoderm development; regulation of lipid storage;
	Sources:Amigo / QuickGO
Orthologs
	4232
	17294
	ENSG00000106484
	ENSMUSG00000051855
	Q5EB52
	Q07646
NM_001253900; NM_001253901; NM_001253902; NM_002402; NM_177524;
	NM_177525
	NM_001252292; NM_001252293; NM_008590
NP_001240829; NP_001240830; NP_001240831; NP_002393; NP_803490;
	NP_803491
	NP_001239221; NP_001239222; NP_032616
	Wikidata
View/Edit Human	View/Edit Mouse

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.

This gene encodes a member of the Alpha/beta hydrolase superfamily and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promoter switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.