METAP2

METAP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B59, 1B6A, 1BN5, 1BOA, 1KQ0, 1KQ9, 1QZY, 1R58, 1R5G, 1R5H, 1YW7, 1YW8, 1YW9, 2ADU, 2EA2, 2EA4, 2GA2, 2OAZ, 5CLS, 5D6E, 5D6F, 5JFR, 5JHU, 5JI6
Identifiers
Aliases	METAP2, MAP2, MNPEP, p67, p67eIF2, methionyl aminopeptidase 2
External IDs	OMIM: 601870; MGI: 1929701; HomoloGene: 4981; GeneCards: METAP2; OMA:METAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	95,515,839 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	93,732,955 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; seminal vesicula; ; Achilles tendon; ; tendon of biceps brachii; ; trabecular bone; ; oral cavity; ; secondary oocyte; ; ganglionic eminence; ; endometrium; ; epithelium of colon;
	Top expressed in
	neural layer of retina; ; tail of embryo; ; genital tubercle; ; muscle of thigh; ; yolk sac; ; morula; ; ventricular zone; ; embryo; ; spermatid; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; metalloexopeptidase activity; hydrolase activity; metal ion binding; aminopeptidase activity; RNA binding; metalloaminopeptidase activity;
Cellular component	cytoplasm; plasma membrane; cytosol;
Biological process	peptidyl-methionine modification; protein processing; N-terminal protein amino acid modification; proteolysis; regulation of rhodopsin mediated signaling pathway; protein initiator methionine removal;
	Sources:Amigo / QuickGO
Orthologs
	10988
	56307
	ENSG00000111142
	ENSMUSG00000036112
	P50579
	O08663
	NM_006838; NM_001317182; NM_001317183; NM_001330246
	NM_019648
	NP_001304111; NP_001304112; NP_001317175; NP_006829
	NP_062622
	Wikidata
View/Edit Human	View/Edit Mouse

Methionine aminopeptidase 2 is an enzyme that in humans is encoded by the METAP2 gene.

Methionine aminopeptidase 2, a member of the dimetallohydrolase family, is a cytosolic metalloenzyme that catalyzes the hydrolytic removal of N-terminal methionine residues from nascent proteins.

peptide-methionine $\rightleftharpoons$ peptide + methionine

MetAP2 is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. Furthermore, MetAP2 is of particular interest because the enzyme plays a key role in angiogenesis, the growth of new blood vessels, which is necessary for the progression of diseases including solid tumor cancers and rheumatoid arthritis. MetAP2 is also the target of two groups of anti-angiogenic natural products, ovalicin and fumagillin, and their analogs such as beloranib.