METTL1

METTL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CKK
Identifiers
Aliases	METTL1, C12orf1, TRM8, TRMT8, YDL201w, methyltransferase like 1, methyltransferase 1, tRNA methylguanosine
External IDs	OMIM: 604466; MGI: 1339986; HomoloGene: 3918; GeneCards: METTL1; OMA:METTL1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,772,119 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,046,365 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; gonad; ; pancreatic ductal cell; ; left adrenal cortex; ; right adrenal gland; ; testicle; ; right lobe of thyroid gland; ; right adrenal cortex; ; stromal cell of endometrium; ; left lobe of thyroid gland;
	Top expressed in
	lacrimal gland; ; yolk sac; ; epiblast; ; embryo; ; blastocyst; ; embryo; ; right kidney; ; morula; ; proximal tubule; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; tRNA binding; tRNA (guanine-N7-)-methyltransferase activity; protein binding; RNA binding;
Cellular component	tRNA methyltransferase complex; nucleolus; nucleus; nucleoplasm; cytosol;
Biological process	methylation; tRNA modification; tRNA processing; tRNA (guanine-N7)-methylation; tRNA methylation; RNA (guanine-N7)-methylation;
	Sources:Amigo / QuickGO
Orthologs
	4234
	17299
	ENSG00000037897
	ENSMUSG00000006732
	Q9UBP6
	Q9Z120
	NM_005371; NM_023032; NM_023033
	NM_010792
	NP_005362; NP_075422
	NP_034922
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.