METTL3

METTL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W
Identifiers
Aliases	METTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hmethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
External IDs	OMIM: 612472; MGI: 1927165; HomoloGene: 10501; GeneCards: METTL3; OMA:METTL3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,511,342 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,542,585 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; body of uterus; ; left lobe of thyroid gland; ; left ovary; ; right ovary; ; right lobe of thyroid gland; ; body of pancreas; ; tibial nerve; ; canal of the cervix;
	Top expressed in
	embryo; ; neural layer of retina; ; saccule; ; primary oocyte; ; Paneth cell; ; primitive streak; ; otic placode; ; embryo; ; epithelium of lens; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; RNA binding; RNA methyltransferase activity; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; mRNA binding; S-adenosyl-L-methionine binding; protein heterodimerization activity; protein binding; mRNA (N6-adenosine)-methyltransferase activity;
Cellular component	RNA N6-methyladenosine methyltransferase complex; nucleoplasm; nuclear speck; nucleus; cytoplasm;
Biological process	rhythmic process; mRNA processing; positive regulation of cap-independent translational initiation; stem cell population maintenance; methylation; mRNA methylation; mRNA destabilization; circadian rhythm; primary miRNA processing; adenosine to inosine editing; RNA methylation; mRNA splicing, via spliceosome; mRNA catabolic process; forebrain radial glial cell differentiation; cellular response to UV; gliogenesis; regulation of T cell differentiation; negative regulation of Notch signaling pathway; regulation of meiotic cell cycle; endothelial to hematopoietic transition; regulation of hematopoietic stem cell differentiation; cellular response to DNA damage stimulus; spermatogenesis; cell differentiation; dosage compensation by inactivation of X chromosome; RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	56339
	56335
	ENSG00000165819
	ENSMUSG00000022160
	Q86U44
	Q8C3P7
	NM_019852
	NM_019721
	NP_062826
	NP_062695
	Wikidata
View/Edit Human	View/Edit Mouse

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene. METTL3 is located on the human chromosome 14q11.2 (Cancer Biology) and out of the METTL protein family, it is the most studied.

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m⁶A). METTL3 forms the m⁶ a methyltransferase complex with METTL14 and WTP and is responsible for a majority of the m⁶a modifications of mRNA. The most common modification being the catalyzation of m⁶a with the methyltransferase complex. METTL3 is expressed in a variety of normal tissues, such as the lymphoid, testis, prostate and fallopian tube tissues. The enzyme is also responsible for mechanisms related to tumor development, RNA stability and maturation, and has suggested roles in ensuring animal survival.