Mitochondrial fission factor

MFF
Identifiers
Aliases	MFF, C2orf33, GL004, mitochondrial fission factor, EMPF2
External IDs	OMIM: 614785; MGI: 1922984; HomoloGene: 137341; GeneCards: MFF; OMA:MFF - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	227,357,836 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	82,730,115 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; gonad; ; ganglionic eminence; ; C1 segment; ; body of pancreas; ; Brodmann area 9; ; anterior cingulate cortex; ; prefrontal cortex;
	Top expressed in
	Epithelium of choroid plexus; ; barrel cortex; ; medullary collecting duct; ; iris; ; substantia nigra; ; medial ganglionic eminence; ; ventral tegmental area; ; retinal pigment epithelium; ; medial vestibular nucleus; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein binding;
Cellular component	integral component of membrane; membrane; synaptic vesicle; peroxisome; synapse; mitochondrial outer membrane; cell junction; integral component of mitochondrial membrane; cytoplasmic vesicle; mitochondrion;
Biological process	mitochondrial fusion; mitochondrial fragmentation involved in apoptotic process; positive regulation of mitochondrial fission; mitochondrial fission; regulation of mitochondrion organization; regulation of peroxisome organization; protein targeting to mitochondrion; peroxisome fission; positive regulation of release of cytochrome c from mitochondria; mitochondrion morphogenesis; protein homooligomerization; release of cytochrome c from mitochondria; positive regulation of protein targeting to membrane;
	Sources:Amigo / QuickGO
Orthologs
	56947
	75734
	ENSG00000168958
	ENSMUSG00000026150
	Q9GZY8
	Q6PCP5
NM_001277061; NM_001277062; NM_001277063; NM_001277064; NM_001277065;
	NM_001277066; NM_001277067; NM_001277068; NM_020194
NM_029409; NM_001310695; NM_001310697; NM_001310699; NM_001372405;
	NM_001372406; NM_001372407; NM_001372408; NM_001372409; NM_001372411; NM_001372412; NM_001372413; NM_001372414
NP_001263990; NP_001263991; NP_001263992; NP_001263993; NP_001263994;
	NP_001263995; NP_001263996; NP_001263997; NP_064579
NP_001297624; NP_001297626; NP_001297628; NP_083685; NP_001359334;
	NP_001359335; NP_001359336; NP_001359337; NP_001359338; NP_001359340; NP_001359341; NP_001359342; NP_001359343
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene. Its primary role is in controlling the division of mitochondria. Mitochondrial morphology changes by continuous fission in order to create interconnected network of mitochondria. This activity is crucial for normal function of mitochondria. Mff is anchored to the mitochondrial outer membrane through the C-terminal transmembrane domain, extruding the bulk of the N-terminal portion containing two short amino acid repeats in the N-terminal half and a coiled-coil domain just upstream of the transmembrane domain into the cytosol. It has also been shown to regulate peroxisome morphology.