MFN1

MFN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T3J
Identifiers
Aliases	MFN1, hfzo1, hfzo2, mitofusin 1
External IDs	OMIM: 608506; MGI: 1914664; HomoloGene: 11481; GeneCards: MFN1; OMA:MFN1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	179,394,936 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	32,633,388 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; body of pancreas; ; gastric mucosa; ; epithelium of colon; ; right hemisphere of cerebellum; ; right uterine tube; ; right auricle of heart; ; skin of leg; ; canal of the cervix;
	Top expressed in
	myocardium of ventricle; ; digastric muscle; ; right ventricle; ; cardiac muscle tissue of left ventricle; ; extraocular muscle; ; soleus muscle; ; extensor digitorum longus muscle; ; muscle of thigh; ; thoracic diaphragm; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; hydrolase activity; GTPase activity;
Cellular component	cytoplasm; mitochondrial outer membrane; mitochondrion; membrane; integral component of mitochondrial outer membrane; outer mitochondrial membrane protein complex; integral component of membrane; intrinsic component of mitochondrial outer membrane;
Biological process	mitochondrial fusion; macroautophagy; GTP metabolic process; mitochondrion localization;
	Sources:Amigo / QuickGO
Orthologs
	55669
	67414
	ENSG00000171109
	ENSMUSG00000027668
	Q8IWA4
	Q811U4
	NM_017927; NM_033540
	NM_024200
	NP_284941
	NP_077162
	Wikidata
View/Edit Human	View/Edit Mouse

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.