MFNG

MFNG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J0A, 2J0B
Identifiers
Aliases	MFNG, MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 602577; MGI: 1095404; HomoloGene: 1803; GeneCards: MFNG; OMA:MFNG - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,486,393 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,657,675 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; lymph node; ; spleen; ; appendix; ; apex of heart; ; bone marrow cells; ; right lung; ; upper lobe of left lung;
	Top expressed in
	ventricular zone; ; medial ganglionic eminence; ; subcutaneous adipose tissue; ; Rostral migratory stream; ; white adipose tissue; ; mesenteric lymph nodes; ; lactiferous gland; ; thymus; ; spleen; ; tunica adventitia of aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity; metal ion binding; glycosyltransferase activity; acetylglucosaminyltransferase activity;
Cellular component	integral component of membrane; integral component of Golgi membrane; Golgi membrane; Golgi apparatus; membrane; extracellular space;
Biological process	pattern specification process; multicellular organism development; positive regulation of protein binding; marginal zone B cell differentiation; positive regulation of Notch signaling pathway; regulation of Notch signaling pathway; protein O-linked fucosylation; blastocyst formation;
	Sources:Amigo / QuickGO
Orthologs
	4242
	17305
	ENSG00000100060
	ENSMUSG00000018169
	O00587
	O09008
	NM_001166343; NM_002405
	NM_008595
	NP_001159815; NP_002396
	NP_032621
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene, a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).

They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.