MGAT1

MGAT1
Identifiers
Aliases	MGAT1, GLCNAC-TI, GLCT1, GLYT1, GNT-1, GNT-I, MGAT, GnTI, mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
External IDs	OMIM: 160995; MGI: 96973; HomoloGene: 1804; GeneCards: MGAT1; OMA:MGAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	180,815,652 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	49,153,857 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; right lung; ; gastric mucosa; ; upper lobe of left lung; ; apex of heart; ; right lobe of thyroid gland; ; left uterine tube; ; spleen; ; left lobe of thyroid gland;
	Top expressed in
	neural layer of retina; ; granulocyte; ; thymus; ; yolk sac; ; right kidney; ; choroid plexus of fourth ventricle; ; proximal tubule; ; tibiofemoral joint; ; molar; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; acetylglucosaminyltransferase activity; metal ion binding; alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity; manganese ion binding;
Cellular component	integral component of membrane; extracellular vesicle; Golgi membrane; Golgi apparatus; extracellular exosome; membrane;
Biological process	protein glycosylation; in utero embryonic development; UDP-N-acetylglucosamine catabolic process; carbohydrate metabolic process; protein N-linked glycosylation; protein N-linked glycosylation via asparagine;
	Sources:Amigo / QuickGO
Orthologs
	4245
	17308
	ENSG00000131446
	ENSMUSG00000020346
	P26572
	P27808
	NM_001114617; NM_001114618; NM_001114619; NM_001114620; NM_002406
	NM_001110148; NM_001110149; NM_001110150; NM_010794
NP_001108089; NP_001108090; NP_001108091; NP_001108092; NP_002397;
	NP_001351306; NP_001351308; NP_001351309; NP_001351310; NP_001351311; NP_001351312; NP_001351313; NP_001351314; NP_001351315; NP_001351316; NP_001351317; NP_001351318; NP_001351319; NP_001351320; NP_001351321; NP_001351322; NP_001351323; NP_001351324
	NP_001103618; NP_001103619; NP_001103620; NP_034924
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.

There are over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.