MGAT2

MGAT2
Identifiers
Aliases	MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
External IDs	OMIM: 602616; MGI: 2384966; HomoloGene: 1806; GeneCards: MGAT2; OMA:MGAT2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	49,623,481 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,233,544 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; decidua; ; periodontal fiber; ; corpus epididymis; ; caput epididymis; ; bronchial epithelial cell; ; tail of epididymis; ; seminal vesicula; ; skin of hip;
	Top expressed in
	parotid gland; ; seminal vesicula; ; epithelium of stomach; ; decidua; ; calvaria; ; right kidney; ; gastrula; ; medullary collecting duct; ; transitional epithelium of urinary bladder; ; pyloric antrum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity; carbohydrate binding; glycosyltransferase activity; manganese ion binding; protein homodimerization activity; metal ion binding;
Cellular component	integral component of membrane; Golgi membrane; Golgi stack; Golgi apparatus; membrane;
Biological process	protein glycosylation; oligosaccharide biosynthetic process; protein N-linked glycosylation; oligosaccharide metabolic process; protein N-linked glycosylation via asparagine;
	Sources:Amigo / QuickGO
Orthologs
	4247
	217664
	ENSG00000168282
	ENSMUSG00000043998
	Q10469
	Q921V5
	NM_002408; NM_001015883
	NM_146035
	NP_002399
	NP_666147
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT2 gene.

The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined.