Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

MGAT4A
Identifiers
Aliases	MGAT4A, GNT-IV, GNT-IVA, GnT-4a, Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
External IDs	OMIM: 604623; MGI: 2662992; HomoloGene: 8153; GeneCards: MGAT4A; OMA:MGAT4A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	98,731,132 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	37,580,097 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of colon; ; renal medulla; ; mucosa of sigmoid colon; ; body of pancreas; ; islet of Langerhans; ; tibia; ; visceral pleura; ; rectum; ; duodenum;
	Top expressed in
	left colon; ; submandibular gland; ; epithelium of small intestine; ; parotid gland; ; jejunum; ; ileum; ; transitional epithelium of urinary bladder; ; duodenum; ; lacrimal gland; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity; acetylglucosaminyltransferase activity; hexosyltransferase activity; metal ion binding; glycosyltransferase activity;
Cellular component	integral component of membrane; extracellular region; Golgi membrane; Golgi apparatus; extracellular exosome; membrane; endoplasmic reticulum lumen;
Biological process	protein glycosylation; N-glycan processing; protein N-linked glycosylation; post-translational protein modification; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11320
	269181
	ENSG00000071073
	ENSMUSG00000026110
	Q9UM21
	Q812G0
	NM_012214; NM_001160154
	NM_001290801; NM_173870
	NP_001153626; NP_036346
	NP_001277730; NP_776295
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A is a type II membrane protein and an enzyme – particularly a glycosyltransferase – that, in addition to the related isoenzyme B (MGAT4B), takes part in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans in Golgi apparatus. Therefore, it is essential for the formation of tri- and tetra-antennary sugar chains. Furthermore, it is involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation with controlling cell-surface expression of SLC2A2 in pancreatic beta cells and, as it is suggested, in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.