MGAT5

MGAT5
Identifiers
Aliases	MGAT5, GNT-V, GNT-VA, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, MGAT5A, glcNAc-T V
External IDs	OMIM: 601774; MGI: 894701; HomoloGene: 1808; GeneCards: MGAT5; OMA:MGAT5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	134,454,621 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	127,416,073 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; middle temporal gyrus; ; Brodmann area 23; ; tibia; ; Pons; ; cardiac muscle tissue of right atrium; ; pars reticulata; ; bronchial epithelial cell; ; myocardium of left ventricle;
	Top expressed in
	Paneth cell; ; renal corpuscle; ; medial geniculate nucleus; ; molar; ; pontine nuclei; ; lateral geniculate nucleus; ; pituitary gland; ; median eminence; ; habenula; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; acetylglucosaminyltransferase activity; glycosyltransferase activity; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity; protein phosphatase inhibitor activity; manganese ion binding;
Cellular component	integral component of membrane; Golgi membrane; extracellular exosome; membrane; Golgi apparatus; extracellular region;
Biological process	protein glycosylation; protein N-linked glycosylation; protein N-linked glycosylation via asparagine; positive regulation of cell migration; negative regulation of protein tyrosine phosphatase activity; positive regulation of receptor signaling pathway via STAT;
	Sources:Amigo / QuickGO
Orthologs
	4249
	107895
	ENSG00000152127
	ENSMUSG00000036155
	Q09328
	Q8R4G6
	NM_002410; NM_001371457
	NM_145128
	NP_002401; NP_001358386
	NP_660110
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.

This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.