Monoacylglycerol lipase
| acylglycerol lipase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Reaction catalyzed by MGLL, in which a free fatty acid (FFA) is released from a monoacylglycerol (MAG) | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.1.23 | ||||||||
| CAS no. | 9040-75-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| monoglyceride lipase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MGLL | ||||||
| NCBI gene | 11343 | ||||||
| HGNC | 17038 | ||||||
| OMIM | 609699 | ||||||
| RefSeq | NM_007283 | ||||||
| UniProt | Q99685 | ||||||
| Other data | |||||||
| EC number | 3.1.1.23 | ||||||
| Locus | Chr. 3 p13-q13.33 | ||||||
| |||||||
Monoacylglycerol lipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL) is an enzyme that, in humans, is encoded by the MGLL gene. MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.