MGST3

MGST3
Identifiers
Aliases	MGST3, GST-III, microsomal glutathione S-transferase 3
External IDs	OMIM: 604564; MGI: 1913697; HomoloGene: 3327; GeneCards: MGST3; OMA:MGST3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,661,796 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,221,410 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; jejunal mucosa; ; Skeletal muscle tissue of rectus abdominis; ; Pons; ; right ventricle; ; thoracic diaphragm; ; apex of heart; ; duodenum; ; Skeletal muscle tissue of biceps brachii; ; mucosa of sigmoid colon;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; olfactory epithelium; ; digastric muscle; ; temporal muscle; ; right ventricle; ; interventricular septum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein binding; glutathione transferase activity; leukotriene-C4 synthase activity; glutathione peroxidase activity; oxidoreductase activity; lyase activity;
Cellular component	integral component of membrane; organelle membrane; extracellular exosome; endoplasmic reticulum membrane; nuclear envelope; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	xenobiotic metabolic process; glutathione derivative biosynthetic process; response to organonitrogen compound; cellular oxidant detoxification; lipid metabolism; leukotriene biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	4259
	66447
	ENSG00000143198
	ENSMUSG00000026688
	O14880
	Q9CPU4
	NM_004528
	NM_025569; NM_029392
	NP_004519
	NP_079845
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.