MHC class I polypeptide–related sequence B

MICB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JE6, 2WY3
Identifiers
Aliases	MICB, PERB11.2, MHC class I polypeptide-related sequence B
External IDs	OMIM: 602436; MGI: 2179989; HomoloGene: 88329; GeneCards: MICB; OMA:MICB - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,511,124 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	18,599,327 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; stromal cell of endometrium; ; lymph node; ; bone marrow; ; gonad; ; bone marrow cells; ; spleen; ; appendix;
	Top expressed in
	urinary bladder; ; uterus; ; lung; ; ovary; ; white adipose tissue; ; adrenal gland; ; zone of skin; ; esophagus; ; muscle tissue; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	natural killer cell lectin-like receptor binding;
Cellular component	integral component of membrane; cell surface; plasma membrane; membrane; extracellular space; external side of plasma membrane;
Biological process	immune system process; gamma-delta T cell activation; viral process; response to heat; cytolysis; adaptive immune response; response to oxidative stress; response to retinoic acid; T cell mediated cytotoxicity; natural killer cell mediated cytotoxicity; regulation of immune response; immune response-activating cell surface receptor signaling pathway; immune response; natural killer cell activation; susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	4277
	243864
ENSG00000231179; ENSG00000224378; ENSG00000206449; ENSG00000227772; ENSG00000238289;
	ENSG00000231372; ENSG00000234218; ENSG00000204516
	ENSMUSG00000040987
	Q29980
	Q8HWE5
	NM_001289160; NM_001289161; NM_005931
	NM_153760; NM_153761
	NP_001276089; NP_001276090; NP_005922
	NP_715641; NP_715642
	Wikidata
View/Edit Human	View/Edit Mouse

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.