MINPP1

MINPP1
Identifiers
Aliases	MINPP1, HIPER1, MINPP2, MIPP, multiple inositol-polyphosphate phosphatase 1, PCH16
External IDs	OMIM: 605391; MGI: 1336159; HomoloGene: 37980; GeneCards: MINPP1; OMA:MINPP1 - orthologs
EC number	3.1.3.80
Gene location (Human)
Chr.	Chromosome 10 (human)
End	87,553,461 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	32,492,764 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; tibia; ; islet of Langerhans; ; Epithelium of choroid plexus; ; jejunal mucosa; ; right adrenal cortex; ; gonad; ; kidney tubule; ; left adrenal gland; ; stromal cell of endometrium;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; abdominal wall; ; primitive streak; ; molar; ; seminal vesicula; ; endocardial cushion; ; skin of back; ; decidua; ; epiblast; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase activity; bisphosphoglycerate 3-phosphatase activity; inositol-hexakisphosphate phosphatase activity; hydrolase activity; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; inositol hexakisphosphate 2-phosphatase activity; acid phosphatase activity; inositol phosphate phosphatase activity; protein histidine phosphatase activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; extracellular exosome;
Biological process	bone mineralization; polyphosphate metabolic process; inositol phosphate metabolic process; ossification; dephosphorylation; protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	9562
	17330
	ENSG00000107789
	ENSMUSG00000024896
	Q9UNW1
	Q9Z2L6
	NM_001178117; NM_001178118; NM_004897
	NM_010799
	NP_001171588; NP_001171589; NP_004888
	NP_034929
	Wikidata
View/Edit Human	View/Edit Mouse

Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.

MINPP1 hydrolyzes the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate and, like PTEN (MIM 601728), has the ability to remove 3-phosphate from inositol phosphate substrates.[supplied by OMIM]