MLH1

MLH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RBN, 4P7A
Identifiers
Aliases	MLH1, mutL homolog 1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1
External IDs	OMIM: 120436; MGI: 101938; HomoloGene: 208; GeneCards: MLH1; OMA:MLH1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	111,100,859 bp
RNA expression pattern
	n/a
	Top expressed in
	genital tubercle; ; tail of embryo; ; saccule; ; otic placode; ; urethra; ; neural layer of retina; ; otic vesicle; ; yolk sac; ; epiblast; ; epithelium of female urethra;
	More reference expression data
Gene ontology
Molecular function	mismatched DNA binding; chromatin binding; single-stranded DNA binding; ATPase activity; protein binding; MutSalpha complex binding; ATP binding; guanine/thymine mispair binding; nucleotide binding; enzyme binding;
Cellular component	chiasma; membrane; male germ cell nucleus; nucleoplasm; chromosome; condensed nuclear chromosome; synaptonemal complex; MutLalpha complex; nucleus; condensed chromosome; late recombination nodule; mismatch repair complex;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; resolution of meiotic recombination intermediates; somatic hypermutation of immunoglobulin genes; reciprocal meiotic recombination; meiotic telomere clustering; male meiotic nuclear division; meiotic metaphase I plate congression; homologous chromosome segregation; oogenesis; male meiosis chromosome segregation; cellular response to DNA damage stimulus; meiotic chromosome segregation; homologous chromosome pairing at meiosis; isotype switching; spermatogenesis; intrinsic apoptotic signaling pathway in response to DNA damage; somatic recombination of immunoglobulin gene segments; negative regulation of mitotic recombination; somatic recombination of immunoglobulin genes involved in immune response; meiotic spindle midzone assembly; DNA mismatch repair; cell cycle; double-strand break repair via nonhomologous end joining; female meiosis chromosome segregation; DNA repair; positive regulation of isotype switching to IgA isotypes; positive regulation of isotype switching to IgG isotypes; meiosis; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	4292
	17350
	ENSG00000076242
	ENSMUSG00000032498
	P40692
	Q9JK91
NM_000249; NM_001167617; NM_001167618; NM_001167619; NM_001258271;
	NM_001258273; NM_001258274
	NM_026810; NM_001324522
NP_000240; NP_001161089; NP_001161090; NP_001161091; NP_001245200;
	NP_001245202; NP_001245203; NP_001341544; NP_001341546; NP_001341547; NP_001341548; NP_001341549; NP_001341550; NP_001341551; NP_001341552; NP_001341556; NP_001341557; NP_001341558; NP_001341559; NP_001341545; NP_001341553; NP_001341554; NP_001341555
	NP_001311451; NP_081086
	Wikidata
View/Edit Human	View/Edit Mouse

DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. The gene is commonly associated with hereditary nonpolyposis colorectal cancer. Orthologs of human MLH1 have also been studied in other organisms including mouse and the budding yeast Saccharomyces cerevisiae.