Matrix metallopeptidase 12

MMP12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JIZ, 1JK3, 1OS2, 1OS9, 1RMZ, 1ROS, 1UTT, 1UTZ, 1Y93, 1YCM, 1Z3J, 2HU6, 2JXY, 2K2G, 2K9C, 2KRJ, 2MLR, 2MLS, 2OXU, 2OXW, 2OXZ, 2POJ, 2W0D, 2WO8, 2WO9, 2WOA, 2Z2D, 3BA0, 3EHX, 3EHY, 3F15, 3F16, 3F17, 3F18, 3F19, 3F1A, 3LIK, 3LIL, 3LIR, 3LJG, 3LK8, 3LKA, 3N2U, 3N2V, 3NX7, 3RTS, 3RTT, 3TS4, 3TSK, 3UVC, 4EFS, 4GQL, 4GR0, 4GR3, 4GR8, 4GUY, 4H30, 4H49, 4H76, 4H84, 4I03, 4IJO, 2N8R, 5I4O, 5I0L, 5I2Z, 5I3M, 5I43
Identifiers
Aliases	MMP12, HME, ME, MME, MMP-12, Matrix metallopeptidase 12
External IDs	OMIM: 601046; MGI: 97005; HomoloGene: 20547; GeneCards: MMP12; OMA:MMP12 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	102,874,982 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	7,369,499 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; mucosa of ileum; ; mucosa of sigmoid colon; ; decidua; ; cartilage tissue; ; appendix; ; amniotic fluid; ; rectum; ; testicle; ; epithelium of nasopharynx;
	Top expressed in
	zygote; ; secondary oocyte; ; lactiferous gland; ; embryo; ; calvaria; ; embryo; ; blastocyst; ; primary oocyte; ; right kidney; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; endopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; serine-type endopeptidase activity; metalloendopeptidase activity; calcium ion binding; collagen binding; zinc ion binding; sequence-specific DNA binding;
Cellular component	extracellular matrix; extracellular region; extracellular space; nucleus; cytoplasm;
Biological process	collagen catabolic process; wound healing, spreading of epidermal cells; extracellular matrix disassembly; positive regulation of epithelial cell proliferation involved in wound healing; wound healing; negative regulation of transcription by RNA polymerase II; proteolysis; protein import into nucleus; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; regulation of defense response to virus by host; negative regulation of type I interferon-mediated signaling pathway; positive regulation of type I interferon-mediated signaling pathway; cellular response to virus; response to hypoxia; elastin catabolic process; negative regulation of endothelial cell-matrix adhesion via fibronectin; extracellular matrix organization; response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	4321
	17381
	ENSG00000262406
	ENSMUSG00000049723
	P39900
	P34960
	NM_002426
	NM_008605; NM_001320076; NM_001320077
	NP_002417
	NP_001307005; NP_001307006; NP_032631
	Wikidata
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Search
PMC	articles
PubMed	articles
NCBI	proteins

macrophage elastase
macrophage elastase
Identifiers
EC no.	3.4.24.65
CAS no.	146888-86-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene.