MMP25

MMP25
Identifiers
Aliases	MMP25, MMP-25, MMP20, MMP20A, MMPL1, MT-MMP 6, MT-MMP6, MT6-MMP, MT6MMP, MTMMP6, matrix metallopeptidase 25
External IDs	OMIM: 608482; MGI: 2443938; HomoloGene: 23375; GeneCards: MMP25; OMA:MMP25 - orthologs
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	23,864,251 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; vena cava; ; olfactory bulb; ; sperm; ; periodontal fiber; ; appendix; ; body of tongue; ; cervix epithelium; ; bone marrow;
	Top expressed in
	granulocyte; ; epiblast; ; bone marrow; ; trigeminal ganglion; ; embryo; ; embryo; ; morula; ; tail of embryo; ; thymus; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	integral component of membrane; extracellular region; anchored component of membrane; membrane; plasma membrane; specific granule membrane; extracellular matrix; extracellular space;
Biological process	inflammatory response; hard palate development; proteolysis; neutrophil degranulation; extracellular matrix organization; collagen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	64386
	240047
	n/a
	ENSMUSG00000023903
	Q9NPA2
	Q3U435
	NM_004142; NM_022468; NM_022718
	NM_001033339; NM_001320258
	NP_071913
	NP_001028511; NP_001307187
	Wikidata
View/Edit Human	View/Edit Mouse

Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins that are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.