Multimerin 1

MMRN1
Identifiers
Aliases	MMRN1, ECM, EMILIN4, GPIa*, MMRN, multimerin 1
External IDs	OMIM: 601456; MGI: 1918195; HomoloGene: 49134; GeneCards: MMRN1; OMA:MMRN1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	89,954,629 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	60,966,362 bp
RNA expression pattern
	Top expressed in
	pericardium; ; right lobe of thyroid gland; ; left uterine tube; ; gallbladder; ; left lobe of thyroid gland; ; testicle; ; decidua; ; ectocervix; ; Achilles tendon; ; canal of the cervix;
	Top expressed in
	carotid body; ; Paneth cell; ; blood; ; gastrula; ; intercostal muscle; ; dermis; ; esophagus; ; conjunctival fornix; ; proximal straight tubule; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; calcium ion binding; extracellular matrix structural constituent;
Cellular component	extracellular region; platelet alpha granule lumen; extracellular matrix; collagen-containing extracellular matrix;
Biological process	platelet degranulation; cell adhesion; blood coagulation; positive regulation of cell-substrate adhesion;
	Sources:Amigo / QuickGO
Orthologs
	22915
	70945
	ENSG00000138722
	ENSMUSG00000054641
	Q13201
	B2RPV6
	NM_007351; NM_001371403
	NM_001163507; NM_027613
	NP_031377; NP_001358332
	NP_001156979; NP_081889
	Wikidata
View/Edit Human	View/Edit Mouse

Multimerin 1, also known as elastin microfibril interfacer 4 (EMILIN-4), is a protein that, in humans, is encoded by the MMRN1 gene.

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is composed of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec/Quebec Platelet Disorder) were found to have a deficiency of platelet multimerin.