MOAP1

MOAP1
Identifiers
Aliases	MOAP1, MAP-1, PNMA4, modulator of apoptosis 1
External IDs	OMIM: 609485; MGI: 1915555; HomoloGene: 11154; GeneCards: MOAP1; OMA:MOAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	93,184,923 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	102,709,920 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; prefrontal cortex; ; Brodmann area 9; ; primary visual cortex; ; right frontal lobe; ; Hypothalamus; ; anterior cingulate cortex; ; Cerebellum; ; cerebellar cortex; ; cerebellar hemisphere;
	Top expressed in
	spermatocyte; ; spermatid; ; neural tube; ; testicle; ; Mesencephalon; ; Hypothalamus; ; dentate gyrus of hippocampal formation granule cell; ; tail of embryo; ; ganglionic eminence; ; Cortex of frontal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; mitochondrial outer membrane; cytosol; mitochondrion;
Biological process	apoptotic process; apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	64112
	64113
	ENSG00000165943; ENSG00000278268
	ENSMUSG00000096458
	Q96BY2
	Q9ERH6
	NM_022151
	NM_001142937; NM_022323
	NP_071434
	NP_001136409; NP_071718
	Wikidata
View/Edit Human	View/Edit Mouse

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.