MOCS3

MOCS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3I2V
Identifiers
Aliases	MOCS3, UBA4, molybdenum cofactor synthesis 3
External IDs	OMIM: 609277; MGI: 1916622; HomoloGene: 6108; GeneCards: MOCS3; OMA:MOCS3 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	50,963,929 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	168,074,514 bp
RNA expression pattern
	Top expressed in
	sperm; ; testicle; ; stromal cell of endometrium; ; gonad; ; ventricular zone; ; ganglionic eminence; ; islet of Langerhans; ; gastrocnemius muscle; ; nasal epithelium; ; prefrontal cortex;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; muscle of thigh; ; right kidney; ; granulocyte; ; embryo; ; primary visual cortex; ; proximal tubule; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; thiosulfate sulfurtransferase activity; molybdopterin-synthase sulfurtransferase activity; metal ion binding; URM1 activating enzyme activity; protein binding; catalytic activity; ubiquitin-like modifier activating enzyme activity; ATP binding; molybdopterin-synthase adenylyltransferase activity; nucleotidyltransferase activity; sulfurtransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	molybdopterin cofactor biosynthetic process; tRNA processing; Mo-molybdopterin cofactor biosynthetic process; metabolism; tRNA wobble uridine modification; tRNA thio-modification; tRNA wobble position uridine thiolation; protein urmylation;
	Sources:Amigo / QuickGO
Orthologs
	27304
	69372
	ENSG00000124217
	ENSMUSG00000074576
	O95396
	A2BDX3
	NM_014484
	NM_001160330
	NP_055299
	NP_001153802
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase, encoded by MOCS2/Mocs2 in mammals). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.