Monooxygenase DBH-like 1

MOXD1
Identifiers
Aliases	MOXD1, MOX, PRO5780, dJ248E1.1, Monooxygenase DBH-like 1, monooxygenase DBH like 1
External IDs	OMIM: 609000; MGI: 1921582; HomoloGene: 22904; GeneCards: MOXD1; OMA:MOXD1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,401,475 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	24,178,688 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; cartilage tissue; ; periodontal fiber; ; gallbladder; ; body of uterus; ; stromal cell of endometrium; ; gastric mucosa; ; myometrium; ; left adrenal gland;
	Top expressed in
	vas deferens; ; lumbar spinal ganglion; ; Epithelium of choroid plexus; ; lip; ; hair follicle; ; skin of external ear; ; molar; ; sciatic nerve; ; external carotid artery; ; efferent ductule;
	More reference expression data
	n/a
Gene ontology
Molecular function	monooxygenase activity; oxidoreductase activity; protein binding; catalytic activity; metal ion binding; copper ion binding; dopamine beta-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; extracellular space; secretory granule membrane; cytoplasm;
Biological process	octopamine biosynthetic process; dopamine catabolic process; norepinephrine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	26002
	59012
	ENSG00000079931
	ENSMUSG00000020000
	Q6UVY6
	Q9CXI3
	NM_015529
	NM_021509
	NP_056344
	NP_067484
	Wikidata
View/Edit Human	View/Edit Mouse

DBH-like monooxygenase protein 1, also known as monooxygenase X, is an enzyme that in humans is encoded by the MOXD1 gene.

DBH-like 1 maintains many of the structural features of dopamine beta-monooxygenase DBH. Since Peptidylglycine alpha-hydroxylating monooxygenase (PHM; EC 1.14.17.3) is homologous to dopamine beta-monooxygenase (DBM; EC 1.14.17.1) this concerns a structural basis for a new family of copper type II, significantly specific for ascorbate-dependent monooxygenases based on the corresponding mouse homolog. The pathway of catecholamine synthesis is a possible catecholamine-binding metabolic copper enzyme domain, a neuron-like property encoding MOX without a signal sequence enzyme metabolism resolving the monooxygenase X chemical pathway of an unknown substrate, exogenous MOX is not secreted, and it localizes throughout the endoplasmic reticulum, in both endocrine or nonendocrine cells.