Mitochondrial pyruvate carrier 2

MPC2
Identifiers
Aliases	MPC2, BRP44, mitochondrial pyruvate carrier 2, SLC54A2
External IDs	OMIM: 614737; MGI: 1917706; HomoloGene: 31675; GeneCards: MPC2; OMA:MPC2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,937,072 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,308,783 bp
RNA expression pattern
	Top expressed in
	sperm; ; thoracic diaphragm; ; left testis; ; right testis; ; right ventricle; ; renal medulla; ; mucosa of sigmoid colon; ; Skeletal muscle tissue of rectus abdominis; ; myocardium of left ventricle; ; liver;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; masseter muscle; ; interventricular septum; ; atrioventricular valve; ; seminiferous tubule; ; extensor digitorum longus muscle; ; digastric muscle; ; right kidney; ; tunica adventitia of aorta; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	pyruvate transmembrane transporter activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion; nucleus; integral component of mitochondrial inner membrane;
Biological process	mitochondrial acetyl-CoA biosynthetic process from pyruvate; positive regulation of insulin secretion involved in cellular response to glucose stimulus; mitochondrial pyruvate transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	25874
	70456
	ENSG00000143158
	ENSMUSG00000026568
	O95563; Q5R3B4
	Q9D023
	NM_001143674; NM_015415
	NM_027430
	NP_001137146; NP_056230
	NP_081706
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial pyruvate carrier 2 (MPC2) also known as brain protein 44 (BRP44) is a protein that in humans is encoded by the MPC2 gene. It is a member of the Mitochondrial Pyruvate Carrier (MPC) protein family. This protein is involved in transport of pyruvate across the inner membrane of mitochondria in preparation for the pyruvate dehydrogenase reaction.