MPGES-1

PTGES
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DWW, 4WAB, 4AL1, 4BPM, 4YL1, 4YL3, 4YK5, 4AL0, 4YL0, 5BQI, 5BQG, 5BQH
Identifiers
Aliases	PTGES, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1, prostaglandin E synthase
External IDs	OMIM: 605172; MGI: 1927593; HomoloGene: 3587; GeneCards: PTGES; OMA:PTGES - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	129,753,042 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	30,819,875 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; nasal epithelium; ; gastric mucosa; ; seminal vesicula; ; cartilage tissue; ; skin of leg; ; mucosa of urinary bladder; ; skin of abdomen; ; nipple; ; minor salivary glands;
	Top expressed in
	blastocyst; ; gastrula; ; morula; ; lactiferous gland; ; decidua; ; right kidney; ; cumulus cell; ; genital tubercle; ; lumbar spinal ganglion; ; granulocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glutathione binding; isomerase activity; prostaglandin-E synthase activity; glutathione transferase activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; mitochondrion;
Biological process	prostaglandin metabolic process; response to cytokine; response to organic cyclic compound; response to retinoic acid; lipid metabolism; cyclooxygenase pathway; fatty acid metabolic process; response to calcium ion; response to lipopolysaccharide; fatty acid biosynthetic process; acute inflammatory response; prostaglandin biosynthetic process; chronic inflammatory response; negative regulation of cell population proliferation; signal transduction; glutathione metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9536
	64292
	ENSG00000148344
	ENSMUSG00000050737
	O14684
	Q9JM51
	NM_004878; NM_198797
	NM_022415
	NP_004869
	NP_071860
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal prostaglandin E synthase-1 (mPGES-1) or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

It is inhibited by crisdesalazine (AAD-2004; GedaCure).