DNA-3-methyladenine glycosylase

MPG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BNK, 1EWN, 1F4R, 1F6O, 3QI5, 3UBY
Identifiers
Aliases	MPG, AAG, ADPG, APNG, CRA36.1, MDG, Mid1, PIG11, PIG16, anpg, N-methylpurine DNA glycosylase
External IDs	OMIM: 156565; MGI: 97073; HomoloGene: 1824; GeneCards: MPG; OMA:MPG - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	85,851 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	32,182,700 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; Descending thoracic aorta; ; right coronary artery; ; stromal cell of endometrium; ; left coronary artery; ; tibial arteries; ; gastric mucosa; ; left adrenal cortex; ; right lung; ; right adrenal gland;
	Top expressed in
	parotid gland; ; proximal tubule; ; seminal vesicula; ; efferent ductule; ; renal corpuscle; ; fossa; ; right kidney; ; lumbar subsegment of spinal cord; ; molar; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-7-methylguanine glycosylase activity; DNA-7-methyladenine glycosylase activity; damaged DNA binding; DNA binding; alkylbase DNA N-glycosylase activity; protein binding; DNA-3-methylguanine glycosylase activity; catalytic activity; hydrolase activity; DNA-3-methyladenine glycosylase activity; DNA N-glycosylase activity;
Cellular component	cytoplasm; mitochondrial nucleoid; mitochondrion; nucleus; nucleoplasm;
Biological process	depurination; DNA dealkylation involved in DNA repair; base-excision repair; cellular response to DNA damage stimulus; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	4350
	268395
	ENSG00000103152
	ENSMUSG00000020287
	P29372
	Q04841
	NM_002434; NM_001015052; NM_001015054
	NM_010822
	NP_001015052; NP_001015054; NP_002425
	NP_034952
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-3-methyladenine glycosylase also known as 3-alkyladenine DNA glycosylase (AAG) or N-methylpurine DNA glycosylase (MPG) is an enzyme that in humans is encoded by the MPG gene.

Alkyladenine DNA glycosylase is a specific type of DNA glycosylase. This subfamily of monofunctional glycosylases is involved in the recognition of a variety of base lesions, including alkylated and deaminated purines, and initiating their repair via the base excision repair pathway. To date, the human AAG (hAAG) is the only glycosylase identified that excises alkylation-damaged purine bases in human cells.