MPP1

MPP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EJY, 2EV8, 3NEY
Identifiers
Aliases	MPP1, AAG12, DXS552E, EMP55, MRG1, PEMP, membrane palmitoylated protein 1, MAGUK p55 scaffold protein 1
External IDs	OMIM: 305360; MGI: 105941; HomoloGene: 1826; GeneCards: MPP1; OMA:MPP1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	154,821,007 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	74,174,622 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; jejunal mucosa; ; trabecular bone; ; bone marrow; ; bone marrow cells; ; duodenum; ; right lung; ; spleen; ; granulocyte;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; tibiofemoral joint; ; blood; ; jejunum; ; ileum; ; right kidney; ; stroma of bone marrow; ; granulocyte; ; endothelial cell of lymphatic vessel; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	guanylate kinase activity; protein binding;
Cellular component	cortical cytoskeleton; cell projection; integral component of plasma membrane; intracellular anatomical structure; membrane; stereocilium; cytosol; plasma membrane; nuclear speck;
Biological process	regulation of neutrophil chemotaxis; signal transduction; GDP metabolic process; GMP metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4354
	17524
	ENSG00000130830
	ENSMUSG00000031402
	Q00013
	P70290
	NM_001166460; NM_001166461; NM_001166462; NM_002436
	NM_008621
	NP_001159932; NP_001159933; NP_001159934; NP_002427
	NP_032647
	Wikidata
View/Edit Human	View/Edit Mouse

55 kDa erythrocyte membrane protein is a protein that in humans is encoded by the MPP1 gene.

Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.