3-mercaptopyruvate sulfurtransferase
| 3-mercaptopyruvate sulfurtransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.1.2 | ||||||||
| CAS no. | 9026-05-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| 3-mercaptopyruvate sulfurtransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MPST | ||||||
| Alt. symbols | MST, TST2, TUM1 | ||||||
| Alt. names | human liver rhodanese | ||||||
| NCBI gene | 4357 | ||||||
| HGNC | 7223 | ||||||
| OMIM | 602496 | ||||||
| PDB | 3OLH | ||||||
| RefSeq | NP_066949 | ||||||
| UniProt | P25325 | ||||||
| Other data | |||||||
| EC number | 2.8.1.2 | ||||||
| Locus | Chr. 22 q123 | ||||||
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In enzymology, a 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2) is an enzyme that catalyzes the chemical reactions of 3-mercaptopyruvate. This enzyme belongs to the family of transferases, specifically the sulfurtransferases. This enzyme participates in cysteine metabolism. It is encoded by the MPST gene.
The enzyme is of interest because it provides a pathway for detoxification of cyanide, especially since it occurs widely in the cytosol and distributed broadly.